9.5. The amino terminal residue is pyroglutamate. Mechanism Of Action In cancer cells, ONCONASE-induced intracellular RNA degradation triggers several biological effects... with induction of differentiation. MCF-7 Breast Cancer Untreated Control MCF-7 Breast Cancer RNP-treated The hyper-condensed chromatin and the morphological changesin the form of multiple...

Paper in Cell Cycle Reports Alfacell's ONCONASE(R) Targets siRNA 07/21/08 Paper in Molecular Cancer Therapeutics Reports that a Novel Combination of Alfacell's ONCONASE(R...) and Rosiglitazone Induces a Synergistic Apoptotic Effect in Several Cancer Cell Lines 07/15/08 Alfacell Announces ONCONASE(R) Distribution and Marketing Agreement with Megapharm for Israel 06... Alfacell Announces Retirement of Chief Executive Officer 04/14/08 Alfacell's ONCONASE(R) Shows Potential as Radiation Sensitizer for Lung Cancer Treatment 04/03/08...

for therapeutic purposes while enabling the development of a new class of therapies for cancer, viral, and other life-threatening diseases. Currently, Tamir is conducting a Phase II clinical... trial with the addition of RANPIRNASE (ONCONASE ) to PEMETREXED plus CARBOPLATIN in patients with non-squamous, non-small cell lung cancer (NSCLC). ONCONASE is a first-in-class... to target cancer cells while sparing normal cells. ONCONASE triggers apoptosis, the natural death of cells, via multiple molecular mechanisms of action. Tamir's proprietary drug...