for encoding genes and also has elements that control contextual gene expression. Epigenetics refers to control of gene expression that is not encoded in the DNA. There are a plethora... of enzymes and proteins in the cell that are responsible for epigenetic control of gene expression, mostly by acting on histone proteins to affect chromatin state. These proteins..., such as epigenetic enzymes, represent entirely new classes of anti-cancer drugs. In collaboration with our Chemistry partner; IntelliSynRD, we are developing novel therapeutics...

alterations in DNA architecture (epigenetics). A key architectural component of DNA is the winding of the double helix around histone proteins with each segment forming... for epigenetic reader proteins which, in turn, serve as recruitment factors to initiate gene transcription. Because of their reversibility and regulation, the lysine acetylation... and other epigenetic factors are highly attractive as drug targets. Our team at Epigenetix continues to develop potent, safe inhibitors of the class of reader proteins. Search...

researchers and access to an exceptional talent pool. Transcriptional control by epigenetic modulators Search for: Research & DevelopmentEpigenetix Science Chemistry Platform Pipeline Home | Contact Us | Login | All rights are reserved by Epigenetix 2013 ...

projects concern epigenetics, mammalian transcriptomics, noncoding RNAs, neuroscience, cancer and drug discovery across several therapeutic areas. A native of Sweden, Claes obtained...