Chapter 1 The Rationale for Kinetic Modeling There are several good reasons for adding kinetic modeling to your skills for biological investigation. First, experience has shown, over and over again, that there is much more information contained in dynamic biological data than can be extracted by sim...

Chapter 6 Writing Rate Laws for Enzymatically Catalyzed Processes The essential principles for writing enzyme rate laws can be seen in the derivation for a simple 1-reactant, 1-product enzyme-catalyzed process where S is the substrate, and P is the product. Binding is immediately seen as essential b...

Responses to the the frequently heard, thinly veiled, criticism that with three parameters you can fit an elephant: Use these with caution. Know your audience! 1. Three parameters define a constant and a single exponential. If we take the constant to represent production of erythrocytes and let the ...

Chapter 5 Writing Rate Laws for Binding Processes Binding is ubiquitous in biological systems. We define binding to be any non-covalent linking of one chemical species to another. Examples of binding are 1) hormone - receptor binding, 2) neurotransmitter - receptor binding, 3) cytokine - receptor bi...

This cybertextbook is needed by advanced undergraduate and graduate students and professionals in the biomedical sciences or in biomedical engineering who want or need to use modern computer modeling approaches to test theories against experimental data. The cybertextbook is focussed on practical ap...