hair cell function in the inner ear and are another sensitive and specific measure of ototoxicity. In several preclinical studies, SPI has showed that its novel chemoprotectant drug... one rodent model of cancer, the chemoprotectant enhanced the tumoricidal activity of cisplatin. Sound Pharmaceuticals, Inc. is a privately held biopharmaceutical company with a focus...

through apoptosis. SPI is focused on the development of drugs to prevent hearing loss and restore hearing in our three product pipelines: Otoprotection, Chemoprotection... at the University of Florida. Chemoprotection Several classes of therapeutic agents including cancer chemotherapy drugs and aminoglycoside antibiotics can cause oxidative stress... chemoprotection was achieved without interfering with the tumor activity of the cisplatin in rat and mouse tumor models (Lynch et al., 2005b). Sound Pharmaceuticals has recently...