PROGENRA, INC
610-644-6974 x319
271 Great Valley Pkwy Ste 300, Malvern, Pennsylvania 19355-1308 , USA
General Info:
progenra inc. is a biotechnology company committed to developing research tools for drug discovery. our focus is the rapidly expanding field of protein degradation in the cell (exemplified by ubiquitin pathway enzymes). through our expertise in this area we are developing strategies to find novel treatments for major medical conditions such as parkinson's disease, cancer, myopathy, arthritis, and osteoporosis.
Products & Services:
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Web Site Results
unique assay technology platforms to screen compounds rapidly against multiple ubiquitin related enzymes, Progenra is developing a pipeline of compounds that modulate DUB and E3... ligase activities. Pipeline About P5091 (USP7) About P13222 (MuRF1) Progenra has identified P5091, a small molecule dual inhibitor of the closely related DUBs USP7 and USP47, both... Weakly inhibits or is inactive vs. other DUBs Is inactive against other classes of cysteine protease In cultured cells, P5091: Inhibits USP7 activity Inhibits growth (singly...
Ubiquitin-based drug discovery is in its initial stage - like kinases and phosphatases fifteen years ago. Deubiquitylating enzymes (DUBs) and ubiquitin E3 ligases, like...
should be efficacious against p53 wild type and mutant tumors owing to the enzymes range of cancer-promoting targets. The related DUB USP47 is also an anticancer target, affecting...
) that details a novel proteomics based method to detect inhibition of intracellular deubiquitylating enzymes (DUBs). Download PDF Date: 10.24.11 Progenra and Tokyo Medical University Form...
Website Links:
Company Profile:
| Contact: | 610-644-6974 x319 |
| Address: |
271 Great Valley Pkwy Ste 300 Malvern, Pennsylvania 19355-1308 , USA |
| Url: | http://www.progenra.com |
| Fax: | 610-644-8616 |
| Year Established: | 2002 |
| Annual Sales: | Below US$1 Million |
| Business Type: | Manufacturer,Service |
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