cell membranes, destabilizing the membranes and leading to pore formation. The large temperature increase associated with electrocution adds to membrane destabilization. The... PEO-PPO-PEO copolymers to have a large beneficial effect on electrocuted cells and tissue. The membrane sealing properties of Maroon's surfactant chaperone technology can preserve... and severity depending on the distance from the center of the burn. Areas at the center exhibit protein denaturation and complete disruption of cell membranes due to high temperatures...

. All of these processes lead to neuronal cell membrane damage which results in the loss of nerve cell function. Disruption of the conducting fibers interrupts the transmission... chaperone technology can potentially have a huge impact on future spinal cord treatment. The cell membrane stabilizing and sealing capabilities of PEO-PPO-PEO copolymers allow... it to mitigate several of the damaging reactions to spinal cord injuries. Because excitotoxicity results in membrane destabilization, a membrane stabilizer such as a PEO-PPO-PEO...

, stroke, and surgical transplantation procedures. Poloxafuse-R comprises a synthetic, biocompatible surfactant copolymer that is capable of sealing porated cell membranes and a free... with cell membranes, facilitating the ingress of exogenous biomacromoleclues and later to seal the same membranes; DNA, proteins, antisense genes, or other molecules that require... for instances of general trauma where a common pathology is damage to the cell membrane. These include, but are not limited to, burn, electrical, radiological, and other chemical...

utilizing its expertise in the biophysics of cellular membrane injury to carry out several R projects for outside contractors. Maroon's intellectual property in the area of cellular... membrane repair has numerous compositions that are available for licensing, which include compositions that will enhance gene transfection efficacy and reduce reperfusion injury...

Loss of cell membrane structural integrity results from all forms of trauma as well as from the most common fatal and disabling diseases such as myocardial infarction and stroke.... Collectively, these conditions represent the principal cause of injury and death in humans. Thus, a safe, practical and effective pharmaceutical strategy to restore membrane function...