of the tumor suppressor, p53 and cell cycle arrest in cancer cells.Recently-identified substrates of USP7, including PTEN, FOXO4, and claspin, suggest that both p53 wild type and p53... mutant tumors can be targeted via USP7. USP47 controls cell content of its substrate Polb, an enzyme responsible for DNA damage repair; its knockdown inhibits the growth of tumor cells... Weakly inhibits or is inactive vs. other DUBs Is inactive against other classes of cysteine protease In cultured cells, P5091: Inhibits USP7 activity Inhibits growth (singly...

Recent Progenra Publications A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance. Chauhan D...,Richardson P,Munshi N,Anderson KC. Cancer Cell.2012 Sep 11;22(3):345-58. Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47 Joseph Weinstock..., neurodegenerative disorders and infectious diseases Edelmann MJ, Nicholson B, Kessler BM,. Expert Review Mol Med. 2011 Nov 17;13:e35. A baker's dozen of ubiquitin. Haas AL, Leach CA. Cell Biochem...

that the parent compound of this series blocks USP7 activity in cells and exhibits antitumor activity in bortezomib-resistant myeloma models (Chauhan et al., Cancer Cell 22 (2012... is significant because among the ~80 known deubiquitylases, USP7 and USP47 are very closely related and USP7 and USP47 exert non-overlapping anticancer cell effects. The latter...

and a related enzyme, USP47. Read More Date: 09.17.12 New Study Demonstrating Progenra's Novel Anti-Tumor Compound Overcome VELCADE (bortezomib) Resistant Multiple Myeloma Cells Researchers... Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance (Chauhan et al, Cancer Cell). Visit Site Date: 11.23.11 New Study Demonstrating the Intracellular Selectivity...

- Significant experience in cell biology and/or high throughput screening and/or expression and purification of recombinant proteins- Knowledge of the ubiquitin field is a plus- Prior... meetings. Requirements: Ph.D. in a life science (Biochemistry, Molecular Biology, Cell Biology, Pharmacology or similar discipline) with 3+ years of laboratory experience; in addition... technologies to assay ubiquitin ligases and de-ubiquitylases- Apply expertise in biochemistry, molecular biology, cell biology, or medicinal chemistry to the generation of clinical...