Testing and Data Interpretation (EMS 2009) The Combined In Vitro and Acellular Comet Assay: Understanding Mechanisms of Genotoxicity (EMS 2009) The Comet Assay: Breaking from... Tradition (EMS 2008) Interpreting Data from in Vitro Genotoxicity Tests Using the Acellular Comet Assay (EMS 2008) Target Organ Selection for the In Vivo Comet Assay: Genotoxicity Versus... Turmorigenesis (EMS 2008) Safety Testing with the in Vitro Comet Assay: Critical Factors in Protocol Design and Data Interpretation (EMS 2007) Cytotoxicity and its Impact on the In...

(EMS 2010) Combining the In Vivo Comet and Micronucleus Assays: A Practical Apprpoach to Genotoxicity Testing and Data Interpreatation (EMS 2009) The Combined In Vitro and Acellular... Comet ASsay: Understanding Mechanisms of Genotoxicity (EMS 2009) The Comet Assay: Breaking from Tradition (EMS 2008) Interpreting Data from in Vitro Genotoxicity Tests Using... the Acellular Comet Assay (EMS 2008) Target Organ Selection for the In Vivo Comet Assay: Genotoxicity Versus Turmorigenesis (EMS 2008) Safety Testing with the in Vitro Comet Assay...

Assay Development Helix3 constantly strives to develop and optimize in vitro and in vivo assays aimed at improving human safety while reducing the use of animals in safety testing...new assays and techniques HELIX3 INC. HomeAbout Helix3 Inc.Our ServicesThe Comet AssayHelix3 NewsComet Assay NewsTechnical DocumentsCareer OpportunitiesContact Us Our Services... of development. We combine our regulatory compliance with scientific problem-solving to help you to optimize your developmental decision tree. Examples of assays developed...

, cell line differences, or cell division, this protocol provides a better alternative to the in vitro comet assay for assessing the dose response curve for the induction of DNA... Strategies Designed to Reduce In Vivo Requirements Helix3 has developed an acellular comet assay protocol In response to the concern that cytotoxic doses in the in vitro standard... acellular comet assay combined with In vitro comet in live cells (either dividing or non-dividing) may also provide valuable mechanistic data that could otherwise go undetected for many...

About Helix3 Inc. HELIX3 INC. U.S. FDA Drug Safety Testing ICH Safety Guidelines European REACH Chemical Regulations EMEA Guidance on Genotoxicity Testing of Medicines Comet Assay... Interest Group U.S. Environmental Mutagen Society Genetic Toxicology Association HomeAbout Helix3 Inc.Our ServicesThe Comet AssayHelix3 NewsComet Assay NewsTechnical... DocumentsCareer OpportunitiesContact Us About Helix3 Inc. Our Staff Helix3 Operations Director, Marie Vasquez has over 20 years of experience developing new assays and innovative techniques...