-relevant context. Cells employ a special class of regulatory proteins called RNA binding proteins (RBPs) to bring together diverse sets of genes needed to regulate or accomplish... complex cellular processes. In contrast to transcription factors that regulate the production of RNA messages, RBPs coordinate the utilization of RNA messages. Thus, cells use RBPs... into discrete clusters that can be independently partitioned and efficiently regulated. Cells exploit this partitioning to regulate the biological fate of the bound mRNA subsets...

Ribonomics: News Publications 2002 Keene JD, Tenenbaum SA (2002). Eukaryotic mRNPs may represent post-transcriptional operons. Molecular Cell. 9:1161-67. For more information... on obtaining the full article text, visit Molecular Cell online at: http://www.molecule.org. Eystathioy T, Chan EK, Tenenbaum SA, Keene JD, Griffith K, Fritzler MJ (2002). A... phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. Mol Biol Cell. 3:1338-51. For more information...

RNA Binding Proteins and Beta-Cell Function and involves application of the Companies proprietary RAS technology for understanding signaling processes important to beta-cell... function. The second grant is entitled Ribonomic Dissection of LRb-expressing Cells and Neurons and is aimed at identifying signaling pathways involved in leptin receptor-regulated... research in two key areas; the regulation of insulin production and pancreatic beta cell function by RNA binding proteins, and discovery of novel therapeutic targets and cellular...

Advantages Advantages The imperfect correlation between the composition and abundance of mRNA and protein in a cell often interferes with our ability to readily make clear... to reverse engineer biological pathways and networks using computational tools, scientists at Ribonomics, Inc. directly illuminate the cells own system for coordination of gene...

the isolation and characterization of functionally related genes in vitro and in vivo. The Companys technology exploits the cells own organizational scheme for protein expression to reveal...