Disease Reversal Posted by CorDynamics on February 13th, 2013 Finding Treatments for an Orphan Drug We have added a powerful capability to our most requested small animal pulmonary..., causing dizziness, shortness of breath and can lead to heart failure. CorDynamics was the first laboratory to report the protective effects of bosentan and sildenafil in this model... timing the initiation of reversal therapy. Our daily data demonstrate that the variability associated with the model is small, even over six weeks of hypoxia. Animals progressed...

team has a vast level of expertise in this area. Our laboratories feature dedicated telemetry suites where we conduct studies in six small- and large-animal species. Over the last... in this area. One way of investigating test articles from both a safety and discovery perspective is to use an instrumented animal equipped to provide information on complete... laboratories. What s interesting was the amount of renewed interest and discussion around very early-stage programs, including those nowhere near ready for GLP safety studies. What...

standard two week toxicology studies, the compound RO5657- a CCR5 antagonist -had induced treatment related myocardial degeneration in previously normal animals. Employing a variety... RO5657, a CCR5 antagonist, had induced torsades de pointes (a life threatening cardiac arrhythmia) in normal, healthy animals. Employing a variety of preclinical cardiovascular... laboratories interrogated over 120 discrete compounds in the isolated perfused heart for their potential to interact with cardiac function. A majority of these studies were...