-appropriate assays for determination of t1/2 and intrinsic clearance: Early discovery screening (single and multiple timepoint assay formats) ND-enabling (in vitro and in vivo... discovery screening IND-enabling (in vitro/in vivo correlations and human clearance predictions) Screening assay: LC-MS/MS analysis of matrix-matched samples from plasma and buffer... (Identification of major, minor, and trace level metabolites from excreta collected during in vivo studies urine, feces, bile) Metabolite ID of circulating metabolites (MIST...

, and pathology and safety evaluations through the capabilities of our in vivo, bioanalytical and histology laboratories. Our exploratory preclinical safety evaluation approach identifies dose...