your chemotherapy. Is your oncologist considering the chemotherapy drug 5-Fluorouracil for you? 5-Fluorouracil, often referred to as 5-FU, is one of the most commonly prescribed..., ovarian, and pancreatic cancers, among others. Yet, about 13-16% of the patients that receive 5-FU experience severe grade 3-4 side effects including nausea, vomiting, diarrhea... factor in the breakdown of 5-FU, so patients with decreased (or deficient) DPD activity cannot effectively metabolize the drug and may experience some of the severe side effects...

to the commonly prescribed chemotherapy drug 5-Fluorouracil caused by a deficiency in the DPD enzyme. Fortunately, for each individual that is scheduled to receive a 5-FU based drug (ie Adrucil... deficient activity, then he/she could be at risk of severe toxicity when exposed to 5-FU, often with the very first dose. Patients with decreased or completely deficient DPD enzyme... (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-FU, and there is ample evidence that a deficiency of DPD is associated with severe toxicity. Patients...

for 5-Fluorouracil (5-FU) Based Chemotherapy Drugs 5-Fluorouracil was first introduced over 50 years ago, but remains one of the most commonly prescribed chemotherapy drugs...% of patients that receive 5-FU experience severe toxicity [1, 2]. These 5-FU associated side effects include nausea, vomiting, diarrhea, neutropenia, mucositis, neuropathy, dermatitis..., hand-foot syndrome, cardiac toxicity, and, in rare cases, death. Dihydropyrimidine dehydrogenase (DPD) is a key enzyme in the metabolism of 5-FU, and partial or complete deficiency...

toxicity to the chemotherapy drug 5-Fluorouracil (5-FU) and 5-FU based-drugs. More How to Order Click here to order the DPD Enzyme Deficiency Test ITT Labs Services Learn more about...