, the persister cells simply repopulate the biofilm that will then disperse and infect other parts of the body. This is what leads to chronic bacterial infections. How are biofilms... that illustrate the negative impact of bacterial biofilms include the fouling of ship hulls (i.e. the accumulation of algae and invertebrates) and infections of indwelling medical... are upwards of 10,000-fold more resistant to antibiotics and 50-80% of all bacterial infections are biofilm-based, molecules that disperse biofilms could be employed as adjuvant therapy...

that they are stable in water from pH 4-11 and temperatures up to 100 C; therefore our molecules are applicable to controlling/eliminating bacterial biofilms in industrial settings. Our... molecules are broad acting and applicable to medicine, agriculture, and industry. Medical Applications Agile compounds have been tested against the following bacterial biofilms and shown... because we have inhibited across bacterial class (both gamma and beta proteobacteria). Pseudomonas aeruginosa (gamma proteobacterium): An opportunistic pathogen of immunocompromised...

' technology. News release. February 2013 Agile Sciences receives $300,000 grant to evaluate technology for treating infective endocarditis. News release. January 2013 Agile Sciences... Agile Sciences' collaboration with scientists at NC State University results in the identification of Agilyte-modified polymers that resist bacterial colonization. This work... for treating multi-drug resistant infections. News release. August 2010 Agile receives a $252,000 NIH SBIR award to validate Agile's biofilm dispersion technology for dental...

Melander Dr. Melander focuses on defining small molecules that inhibit and disperse bacterial biofilms. He received his Ph.D. in organic chemistry from Columbia University in 1998... Wellcome, Inc. for nearly 11 years, where he directed a number of drug development programs in the anti-infectives and oncology areas, resulting in the submission and approval of one NDA..., Hepatitis C infection, endocrine problems, sleep disorders, depression, pain, migraine, schizophrenia, and Alzheimer s disease. After graduating from Stevens Institute of Technology...